Prof. Dr. Marga C. Lensen

Curriculum:

 

Current position: Junior Professor

Technical University Berlin, Germany

“Nanostrukturierte Biomaterialien / Nanopatterned Biomaterials”

 

2006-2010: Junior research group leader

Sofja Kovalevskaja Award (Alexander von Humboldt Foundation, BMBF)

“Nano- and micro-patterned biomaterials for specific biointeraction”

DWI an der RWTH Aachen e.V., Germany

TU Berlin, Germany

Nanotechnology

 

2005-2006: Postdoc

Humboldt research fellowship (Alexander von Humboldt Foundation)

“Anchoring molecular wires via templated self-assembly”

DWI an der RWTH Aachen e.V., Germany 

Macromolecular chemistry (Prof. Martin Möller)

 

2000-2005: PhD

Netherlands’ research school of combination: catalysis (NRSC-C)

“Catalytic porphyrin nano-assemblies”

Radboud University Nijmegen, The Netherlands

Supramolecular Chemistry (Prof. Roeland J. M. Nolte, Prof. Alan E. Rowan)

 

1995-2000: MSc, BSc

Molecular Sciences - Physical and organic chemistry

Wageningen University, The Netherlands

Organic Chemistry (Prof. Dr. Ernst J. R. Sudhölter)

Molecular Physics (Prof. Dr. Tjeerd J. Schaafsma)

Akzo Nobel Chemicals – Chelates (Industry) (Dr. Peter Nieuwenhuizen)

Publications:

T. Sabel, M. C. Lensen "Function and structure – Combined optical functionality and specific bio-interaction for multifunctional biomedical materials" Journal of Medical Materials and Technologies, 2017, 1(2) (Special Issue Proceedings of 4th Euro BioMAT): 5-7.

Cigdem Yesildag, Christoph Bartsch, Gonzalo de Vicente and Marga C. Lensen “Novel Wet Micro-Contact Deprinting Method for Patterning Gold Nanoparticles on PEG-Hydrogels and Thereby Controlling Cell Adhesion” Polymers, 2017, 9(5): 176. DOI: 10.3390/polym9050176

Fang Ren, Cigdem Yesildag, Zhenfang Zhang, Marga C. Lensen “Surface Patterning of Gold Nanoparticles on PEG-Based Hydrogels to Control Cell Adhesion” Polymers, 2017, 9(5): 154. DOI: 10.3390/polym9050154

Fang Ren, Cigdem Yesildag, Zhenfang Zhang, Marga C. Lensen “Functional PEG-Hydrogels Convey Gold Nanoparticles from Silicon and Aid Cell Adhesion onto the Nanocomposites” Chem. Mater., 2017, DOI: 10.1021/acs.chemmater.6b03548

G. de Vicente, C. Strehmel, M.C. Lensen* "Controlling Cellular Adhesion and Migration on Intrinsically Non-Adhesive Poly(Ethylene Glycol) Hydrogels via Surface Micro-Patterning" in ‘Advances in Chemistry Research. Vol. 38’ (ISBN: 978-1-53612-130-8) Nova Publishers, Ed.: James C. Taylor, 2017, Chapter 4.

T. Sabel, M.C. Lensen "Volume Holography: Novel Materials, Methods and Applications" in ‘Holographic Materials and Optical Systems’ (ISBN 978-953-51-3038-3) InTech- Open Access Publisher, Ed.: I. Naydenova, T. Babeva, and D. Nazarova, 2017, Chapter 1, page 1-25.

Matthias P. Exner, Tilmann Kuenzl, Tuyet Mai T. To, Zhaofei Ouyang, Sergej Schwagerus, Michael G. Hoesl, Christian P. R. Hackenberger, Marga C. Lensen, Sven Panke, Nediljko Budisa* "Design of S-Allylcysteine in Situ Production and Incorporation Based on a Novel Pyrrolysyl-tRNA Synthetase Variant" ChemBioChem, 2016, 17: DOI: 10.1002/cbic.201600537

Gonzalo de Vicente and Marga C. Lensen* "Topographically and elastically micropatterned PEG-based hydrogels to control cell adhesion and migration" European Polymer Journal, 2016, 78: 290-301.

DOI: 10.1016/j.eurpolymj.2016.03.020

 

Zhikun Zheng*, Xianghui Zhang, Christof Neumann, Daniel Emmrich, Andreas Winter, Henning Vieker, Wei Liu, Marga Lensen, Armin Gölzhäuser and Andrey Turchanin "Hybrid van der Waals heterostructures of zero-dimensional and two-dimensional materials" Nanoscale, 2015, 7(32): 13393-13397. DOI: 10.1039/c5nr03475b

 

Christine Strehmel, Heidi Perez-Hernandez, Zhenfang Zhang, Axel Löbus, Andrés F. Lasagni and Marga C. Lensen* "Geometric Control of Cell Alignment and Spreading within the Confinement of Anti-Adhesive Poly(Ethylene Glycol) Microstructures on Laser-Patterned Surfaces" ACS Biomater. Sci. Eng., 2015, 1(9): 747-752. DOI: 10.1021/ab5001657

 

Changzhu Wu, Christine Strehmel, Katharina Achazi, Leonardo Chiappisi, Jens Dernedde, Marga C. Lensen, Michael Gradzielski, Marion B. Ansorge-Schumacher, and Rainer Haag* "Enzymatically Crosslinked Hyperbranched Polyglycerol Hydrogels as Scaffolds for Living Cells" Biomacromolecules, 2014, 15(11): 3881-3890. DOI: 10.1021/bm500705x

 

Zhenfang Zhang, Axel Loebus, Gonzalo de Vicente, Fang Ren, Manar Arafeh, Zhaofei Ouyang and Marga C. Lensen* "Synthesis of Poly(ethylene glycol)-based Hydrogels via Amine-Michael Type Addition with Tunable Stiffness and Postgelation Chemical Functionality" Chem. Mater., 2014, 26(12): 3624–3630. DOI: 10.1021/cm500203j

 

Susan Kelleher, Zhenfang Zhang, Axel Löbus, Christine Strehmel and Marga C. Lensen* "Blending PEG-based polymers and their use in surface micro-patterning by the FIMIC method to obtain topographically smooth patterns of elasticity" Biomaterials Science, 2014, 2(3): 410–418. DOI: 10.1039/c3bm60218d

 

Jingyu Chen, Manar Arafeh, Amandine Guiet, Diana Felkel, Axel Loebus, Susan Kelleher, Anna Fischer, Marga Lensen* "Hybrid Hierarchical Patterns of Gold Nanoparticles and Poly(Ethylene Glycol) Microstructures" Journal of Materials Chemistry C, special issue “Nanofabrication” (on invitation); 2013, 1(46): 7709–7715. DOI: 10.1039/c3tc30811a

 

V. A. Schulte, D. F. Alves, P. P. Dalton, M. Moeller, M. C. Lensen* and P. Mela* "Micro-Engineered PEG Hydrogels: 3D Scaffolds for Guided Cell Growth" Macromolecular Bioscience, 2013, 13(5): 562–572. DOI: 10.1002/mabi.201200376

 

Christine Strehmel, Zhenfang Zhang, Nadine Strehmel and Marga C. Lensen* "Cell phenotypic changes of mouse connective tissue fibroblasts (L-929) to poly(ethylene glycol)-based gels" Biomaterials Science (on invitation); 2013, 1: 850-859. DOI: 10.1039/c3bm60055f

 

R. Tsekov* and M. C. Lensen "Brownian motion and temperament of living cells" Chinese Physics Letters, 2013, 30(7): 070501. DOI: 10.1088/0256-307X/30/7/070501

 

Susan Kelleher, Aniek Jongerius, Axel Loebus, Christine Strehmel, Zhenfang Zhang and Marga C. Lensen* "AFM Characterisation of elastically micropatterned surfaces fabricated by Fill-Molding In Capillaries (FIMIC) and investigation of the topographical influence on cell adhesion to the patterns" Advanced Engineering Materials (special issue Advanced Biomaterials; Euro Biomat Jena), 2012, 14(3): B56-B66. DOI: 10.1002/adem.201180087

M. C. Lensen*, M. Diez, and V. A. Schulte "Patternable biomaterials; elastomers for biomedical applications" in ‘Elastomers: Types, Properties and Applications‘ (ISBN: 978-1-61470-198-9) Nova Publishers, Ed.: J. Balcazara and E. Paules, 2012, Chapter 2, page 37-58.

M. C. Lensen* "Micro- and Nanopatterned Biomaterials: Fundamental Research for Tissue Engineering Applications" BioTOPics, 2012, 43 (Biomaterials in Medicine): 16-17.

 

Vera A. Schulte, Mar Diez, Martin Möller, Marga C. Lensen* “Topography induced cell adhesion to Acr-sP(EO-stat-PO) hydrogels: the role of protein adsorption” Macromolecular Bioscience 2011 in press

M. C. Lensen*, V. A. Schulte, M. Diez "Cell adhesion and spreading on an intrinsically anti-adhesive PEG biomaterial" in ‘Biomaterial, Book 1’ (ISBN 978-953-307-418-4) InTech- Open Access Publisher, Ed.: R. Pignatello, 2011, Chapter 20, page 397-414.

 

Mar Diez, Vera A. Schulte, Filippo Stefanoni, Carlo F. Natale, Francesco Mollica, Claudia M. Cesa, Jingyu Chen, Martin Möller, Paolo A. Netti, Maurizio Ventre and Marga C. Lensen* “Molding Micropatterns of Elasticity on PEG-based Hydrogels to Control Cell Adhesion and Migration” Advanced Engineering Materials (Advanced Biomaterials) 2011, 13 (4): n/a. doi: 10.1002/adem.201080122, in press.

 

V. A. Schulte, M. Diez, M. Möller and M. C. Lensen* “Combined influence of substrate stiffness and surface topography on the anti-adhesive properties of Acr-sP(EO-stat-PO) hydrogels” Biomacromolecules, 2010, 11 (12): 3375–3383.

 

V. A. Schulte, Y. Hu, M. Diez, D. Bünger, M. Möller and M. C. Lensen* “A hydrophobic perfluorinated polyether elastomer as a patternable biomaterial for cell culture and tissue engineering” Biomaterials 2010, 31 (33): 8583 – 8595.

V. A. Schulte, M. Díez, M. Möller and M. C. Lensen* "Cellular responses to physically and mechanically patterned biomaterials" eCM Journal 2010, 20: 157.

 

M. Bartneck*, V. A. Schulte, N. Paul, M. Diez, M. C. Lensen and G. Zwadlo-Klarwasser “Induction of specific macrophage subtypes by defined micropatterned structures” Acta Biomaterialia 2010, 6 (10): 3864-3872.

 

S. Gilles, M. Diez, A. Offenhäusser, M. C. Lensen and D. Mayer* “Deformation of nanostructures on polymer stamps during soft UV nanoimprint lithography” Nanotechnology 2010, 21: 245307-13.

 

J. Chen, P. Mela, M. Möller and M. C. Lensen* “Micro-contact deprinting: a technique to pattern gold nanoparticles” ACS Nano 2009 3 (6): 1451-1456.

 

M. Diez, P. Mela, V. Seshan, M. Möller and M. C. Lensen* “Nanomolding of PEG-based hydrogels with sub-10 nm resolution” Small 2009, 5 (23): 2756-2760.

 

R. Tsekov* and M. C. Lensen “Brownian motion and temperament of living cells” arXiv 2009, 0910.0927v2.

 

V. A. Schulte, M. Díez, M. Möller and M. C. Lensen* “Surface Topography induces Fibroblast Adhesion on intrinsically non-adhesive Poly(ethylene Glycol) Substrates” Biomacromolecules 2009, 10 (10): 2795-2801.

 

M. Bartneck, V. Schulte, N. Paul, M. Lensen and G. Zwadlo-Klarwasser “Topographical control of human primary macrophages by different perfluoropolyether (PFPE) microstructures.” Biomaterialien 2009, 10, Heft 3/ 4: 136.

 

Marga C. Lensen,* Vera A. Schulte, Jochen Salber, Mar Diez, Fabian R. Menges, Martin Möller "Cellular responses to novel, micro-patterned biomaterials” Pure Appl. Chem., 2008, 80 (11): 2479–2487.

 

Marga C. Lensen,* Vera A. Schulte, Mar Díez, Petra Mela and Martin Möller “Micro- and f-patterned Surfaces for Specific Biointeraction” PMSE Preprint 2008, 99: 86.

 

Marga C. Lensen,* Mar Díez, Vera A. Schulte, Petra Mela, and Martin Möller “Nano- and micro-patterned biomaterials” J. Fudan Univ. – Natural Science 2007, 46: 706.

 

Marga C. Lensen,* Petra Mela, Ahmed Mourran, Juergen Groll, Jean Heuts, Haitao Rong, Martin Möller “Micro- and Nanopatterned Star Poly(Ethylene Glycol) (PEG) Materials Prepared by UV-Based Imprint Lithography”, Langmuir 2007, 23(14):7841-7846.

 

Marga C. Lensen, Johannes (Hans) A. A. W. Elemans, Sandra J. T. Van Dingenen, Jan W. Gerritsen, Sylvia Speller, Alan E. Rowan and Roeland J. M. Nolte “Giant Porphyrin Disks: Control of Their Self-Assembly at Liquid-Solid Interfaces through Metal-Ligand Interactions” Chem.-Eur.J. 2007, 13: 7948 - 7956.

 

Marga C. Lensen, Martin Möller “Method for preparation of surface-structured bulk hydrogels for bioapplications” European Patent EP 06 011 868.4 2006. 

 

Marga C. Lensen, Martin C. Feiters, Roeland J. M. Nolte, and Alan E. Rowan “Supramolecular aggregates of porphyrin oligomers connected by DABCO.” Exp. rep. 2004, Forschungszentrum Jülich GmbH, 2005: 280-281.

 

Marga C. Lensen, Johannes (Hans) A. A. W. Elemans, Alan E. Rowan, and Roeland J. M. Nolte “Self-assembled catalytic porphyrin architectures.” J. Porphyrins Phthalocyanines 2004, 8: 745.

 

Marga C. Lensen, Ken Takazawa, Johannes (Hans) A. A. W. Elemans, Cecile R. L. P. N. Jeukens, Peter C. M. Christianen, Jan-Cees Maan, Alan E. Rowan, and Roeland J. M. Nolte “Aided self-assembly of porphyrin nanoaggregates into ring-shaped architectures.” Chem.-Eur. J. 2004, 10: 831-839.

 

Cecile R. L. P. N. Jeukens, Marga C. Lensen, Frans J. P. Wijnen, Johannes (Hans) A. A. W. Elemans, Peter C. M. Christianen, Alan E. Rowan, Jan W. Gerritsen, Roeland J. M. Nolte, and Jan-Cees Maan “Polarized absorption and emission of ordered self-assembled porphyrin rings.” Nano Lett. 2004, 4: 1401-1406.

 

Marga C. Lensen, Sandra. J. T. Van Dingenen, Johannes (Hans) A. A. W. Elemans, Harm P. Dijkstra, Gerard P. M. van Klink, Gerard van Koten, Jan W. Gerritsen, Sylvia Speller, Roeland J. M. Nolte, and Alan E. Rowan “Synthesis and self-assembly of giant porphyrin discs.” Chem. Commun. 2004: 762-763.

 

Johannes (Hans) A. A. W. Elemans, Marga C. Lensen, Jan W. Gerritsen, Herman van Kempen, Sylvia Speller, Roeland J. M. Nolte, and Alan E. Rowan “Scanning probe studies of porphyrin assemblies and their supramolecular manipulation at a solid-liquid interface.” Adv. Mater. 2003, 15: 2070-2073. 

 

Johannes (Hans) A. A. W. Elemans, Marga C. Lensen, Sandra J. T. Van Dingenen, Jan W. Gerritsen, Herman Van Kempen, Roeland J. M. Nolte, Alan E. Rowan, and Sylvia Speller “STM studies on nanosized porphyrin wheels at the solid-liquid interface.” AIP Conference Proceedings, 2003, Vol. 696: 508-512.

 

Marga C. Lensen, Mariangela Castriciano, Ruud G. E. Coumans, Jantien Foekema, Alan E. Rowan, Luigi M. Scolaro, and Roeland J. M. Nolte “Hexakis (pyridyl-functionalised porphyrinato)benzene as a building block for the construction of multi-chromophoric arrays.” Tetrahedron Lett. 2002, 43: 9351-9355.

Invited Lectures:

- University of Düsseldorf, Organic Chemistry (2006); Prof. Ritter

- Center of NanoTechnology (CeNTech) ünster (2006); Prof. Fuchs

- Aachen Polymer Chain (APC) Talks (2007); DWI / RWTH Aachen; Prof. M öller

- 17th International Symposium FCFP-XVII (2007); Shanghai, China; Prof. Wu

- Forschungszentrum Juelich, IBN2 (2007); Prof. Offenhäusser

- Institute of Physical Chemistry (IPC) (2007); RWTH Aachen; Prof Richtering

- Colloquium of Unifying Concepts in Catalysis (UniCat), Technical University Berlin (2008); Prof. Hildebrandt

- Max Planck Institute für Metallforschung, Stuttgart (2008); Dr. Kemkemer

- Colloquium of Unifying Concepts in Catalysis (UniCat), Technical University Berlin (2008); Prof. Hildebrandt 

- Max Planck Institute für Metallforschung, Stuttgart (2008); Dr. Kemkemer

- Chalmers University, Gothenburg, Sweden (2008); Prof. Gold

- Technical University Delft, DelftChemTech, The Netherlands (2008); Prof. Sudhölter

- Forschungszentrum Juelich, IBN2 (2009); Dr. Mayer

- ESF-EMBO Conference "Biological Surfaces and Interfaces", Spain (2009); Prof. Spatz and Prof. Gold

- University of Naples "Federico II", Dept. of Materials and Production Engineering, Italy (2009); Prof. Netti 

- University College Dublin (UCD), Conway Institute, Ireland (2009); Prof. Lee

- Bielefeld Institute for Biophysics and Nanoscience (2010); Dr. Turchanin

- Freie Universität Berlin (2010); Prof. Haag

- TU Berlin, Institut of Physics (2011); Prof. Stark

- Max Planck Institute of Colloids and Interfaces, Potsdam (2011) Dr. John Dunlop / Prof. Peter Fratzl

Oral contributions to international conferences:

At 17th International Symposium on Fine Chemistry and Functional Polymers (FCFP-XVII) & IUPAC 3rd International Symposium on Novel Materials and Synthesis (NMS-II1), Shanghai, China (2007):

M. C. Lensen*, M. Diez, V. A. Schulte, P. Mela, M. Möller "Nano- and micro-patterned biomaterials"

Invited by symposium organiser Prof. Wu (Fudan University)


At Gordon Research Conference "Signaling by Adhesion Receptors", South Hadley, MA, USA (2008):

V.A. Schulte, M. Diez, M. öller and M.C. Lensen "Surface Topography induces Fibroblast Adhesion and Spreading on two intrinsically non-fouling Biomaterials"

 

At World Biomaterials Conference, Amsterdam, The Netherlands (2008):

M. C. Lensen, V. A. Schulte, M. Diez, P. Mela, M. Möller "Cellular responses to novel nano- and micro-patterned biomaterials"

 

At ACS (American Chemical Society) Meeting, section PMSE (Polymer Materials, Science and Engineering), Philadelphia, USA (2008):

M. C. Lensen, V. A. Schulte, M. Diez, P. Mela, M. Moeller "Micro- and nano-patterned surfaces for specific biointeraction"

 

At Gordon Research Conference on "Fibronectin, Integrins & Related Molecules", Ventura, CA, USA (2009):

V.A. Schulte, M. Diez, M. Bartneck, G. Zwadlo-Klarwasser, M. Möller and M.C. Lensen "Cellular Reactions to patterned biointerfaces: Influence of surface wettability and µm-patterns"

 

At ESF-EMBO Symposium on "Biological Surfaces and Interfaces", Sant Feliu de Guixols, Spain (2009):

M. Diez, J. Chen, P. Mela, V. A. Schulte, C. M. Cesa, F. Stefanoni, M. Ventre, F. Mollica, P. A. Netti, M. Möller and M. C. Lensen* "Cellular behavior on micro- and nanopatterned hydrogels"

Invited by symposium organisers Prof. Gold and Prof. Spatz

 

At 23nd Annual Meeting of the European Macrophage and Dendritic Cell Society, Regensburg, Germany (2009):

M. Bartneck, V. Schulte, M. Lensen and G. Zwadlo-Klarwasser "Effects of different microstructured PFPE surface structures on macrophage phenotype and cytokine production" 

 

At 97th Meeting of the American Association of Immunologists, Baltimore, Maryland, USA (2010):

M. Bartneck*, H. A. Keul, V. Schulte, M. Lensen, J. Groll and G. Zwadlo-Klarwasser. "Control of the inflammatory response of primary human macrophages by microstructures and surface chemistry"

Invited oral presentation (one hour) by BenderMedsystems

 

J. Chen, M. Diez, V.A. Schulte, F. Stefanoni, M. Ventre, F. Mollica, P. Netti and M.C. Lensen* "Cell adhesion and migration on patterned hydrogels"

Invited to submit the lecture as a manuscript for Advanced Engineering Materials (Advanced Biomaterials)

 

J. Chen, M. Diez, V. A. Schulte, and M. C. Lensen* "Patterned hydrogels to manipulate cell adhesion and migration" Invited by the organiser Prof. Thomas
Invited to submit the lecture as a chapter for the book ‘Advances in Natural Polymers, Biopolymers, Biomaterials, and Their Composites, Blends and IPNs’

 

V. A. Schulte, M. Diez, J. Chen, and M. C. Lensen* "Physically and mechanically patterned hydrogels to manipulate cell adhesion and migration" Invited by the organisers Prof. Maynard and Prof. Harth

 

M. C. Lensen* "Cells’ responses to micro- and nano-patterned BIOINTERFACES" Plenary lecture; invited by the organiser Prof. Jandt
Invited to submit the lecture as a manuscript for Advanced Engineering Materials (Advanced Biomaterials)

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